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Drug Interactions With MMRV

Drug Interactions With MMRV Explained

The following sections explain in detail the potentially negative interactions that can occur when MMRV is combined with any of the drugs listed above.
Immune Globulins or Blood Products
Immune globulins or blood products may decrease the effectiveness of live vaccines like MMRV. Vaccination with MMRV should be postponed for three months or more after a dose of immune globulin or after receiving a blood product.
If you are taking an immunosuppressant, you may not receive the full benefit of MMRV. More importantly, with live vaccines such as MMRV, people taking immunosuppressants may have a higher risk of actually developing the infection from the vaccine, albeit it a usually mild form. In many situations, MMRV may not be recommended for people taking immunosuppressants. Your healthcare provider will evaluate your individual situation before making a recommendation.
People should avoid taking any salicylates (including aspirin) for six weeks after receiving MMRV, due to the possible risk of Reye's syndrome (a potentially fatal condition). This drug interaction is theoretical, based on cases of Reye's syndrome seen when people with chickenpox took aspirin (MMRV contains a chickenpox vaccine).
Tuberculin Skin Tests
Live vaccines may interfere with the accuracy of tuberculin skin tests, which are used to screen for tuberculosis, perhaps increasing the risk of false-negative results. Therefore, you should wait at least four to six weeks after receiving the MMRV vaccine before having a tuberculin skin test. However, it is safe to get the tuberculin skin test before or at the same time as the vaccine.

Final Thoughts

It is possible that not all drug interactions with MMRV were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
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