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Available as an injection, the MMRV vaccine is given to children to help protect against measles, mumps, rubella, and varicella (chickenpox). This vaccine contains live viruses, which are altered in a way to prevent these diseases. Although most people tolerate MMRV well, side effects may still occur and can include reactions at the injection site, irritability, and fever.

What Is MMRV?

MMRV (ProQuad®) is a vaccine used to provide protection against measles, mumps, rubella, and varicella (chickenpox). It is approved for use in individuals 12 months through 12 years of age.
(Click What Is MMRV Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any vaccine, MMRV can cause side effects. However, not everyone who receives the vaccination will have problems. Most children tolerate it quite well, with only minor side effects, if any.
Some of the most common side effects seen with MMRV include but are not limited to:
  • Injection site reactions (pain, tenderness, swelling, or redness at the injection site)
  • Fever
  • Irritability.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
(Click Side Effects of the MMRV Vaccine to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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